The changes of cellular immunity in 560 cases of hand-foot-mouth disease children / 中国医师杂志

Objective To investigate the relationship of cellular immunity of the hand-foot-mouth disease (HFMD) children and the disease severity and the variation following the recovery of disease.Methods A total of 560 HFMD cases was collected,and divided into severe and common groups.Another 120 cases were collected for comparison.T cell subsets (CD3 +,CD4 +,and CD8 +) rates were tested.The difference in cell immunity in each group were compared,and the comparison of cell immunity improv-ment during acute and recovery periods was conducted at the same time.Results In the 560 cases of children with HFMD,CoxA16-positive rate in common group was higher than that in severe group (x2 =280.72,P ＜0.01,severe cases); EV71 and other virus positive rates in severe group were higher than that in common group (x2 =127.75,P ＜ 0.01,x2 =5.43,P ＜ 0.05).Cell immunity was compared among3 groups (t =9.82,4.98,3.06); CD3+,CD4+,CD8+ results,tested within 2h after admission and after 1 week,were compared between severe and common groups (common group t =7.73,3.86,4.71; severe group t =6.13,2.60,3.36).Compared to severe group,cell immunity improvement was more obvious between before and after 1-week treatment in common group (t =2.57,2.51,2.95).The difference was statistically significant (P ＜ 0.05).Conclusions According to the etiology test of children with HFMD,CoxA16-positive rate was higher in common group; EV71 and other virus positive rates were higher in severe group.Cell immunity function decreased in severe and common group at the beginning of the disease; it was,however,significantly restored after 1-week treatment; and it was related to the severity of clinical symptoms.

Detection of plasma PT, APTT, TT and Fib in patients with oral maxillofacial malignant tumor / 实用口腔医学杂志

Objective:To explore the coagulation indexes in patients with oral maxillofacial malignant tumor.Methods:Sysmex CA-50 automatic blood coagulation testing machine,reagents and quality control produced by Dade Behring company were adopted to detect the coagulation indexes of PT, APTT, TT and Fib in the plasma of 93 cases with oral maxillofacial malignant tumor,44 of benign tumor and 79 of healthy subjects.Results:APTT(s) in patients with oral maxillofacial malignant tumor,in those with benign tumor and in the healthy subjects was 31.57?2.38, 32.86 ? 2.47 and 33.63?2.89 respectively(P0.05).Conclusion:APTT is shorter in patients with oral maxillofacial malignant tumor.